| Cyclosporine treatment of steroid-refractory ulcerative colitis during pregnancy. | |
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MedLine Citation:
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PMID: 19137604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cyclosporine is considered a safe and effective treatment of severe steroid-refractory ulcerative colitis (UC). However, few data are available concerning its safety profile in pregnant women. We report here the experience of 5 GETAID centers. METHODS: In a retrospective study data on patients with severe UC treated with cyclosporine during pregnancy were extracted from medical records of consecutive patients treated between 2001 and 2007. RESULTS: Eight patients (median age 30.5 years old) were identified. At the time of flare-up the median duration of pregnancy was 11.5 weeks of gestation (range 4-25). Seven patients had pancolitis. All patients had more than 3 commonly used clinical and biological severity criteria. Three patients had severe endoscopic lesions and 5 patients had not. All patients received intravenous corticosteroids for at least 7 days before introduction of cyclosporine. Two patients received azathioprine during treatment with cyclosporine. No severe infections or other complications due to treatment were observed. Treatment was effective in 7/8 patients. One patient received infliximab due to cyclosporine therapy failure with a good outcome. No colectomy was performed during pregnancy. Seven pregnancies were conducted to term, but 1 in utero death occurred due to maternal absence of S-protein. Two newborns were premature, including 1 case of hypotrophy. No malformations were observed. CONCLUSIONS: In our experience, treatment with cyclosporine for steroid-refractory UC during pregnancy can be considered safe and effective. |
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Authors:
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Julien Branche; Antoine Cortot; Arnaud Bourreille; Benoît Coffin; Martine de Vos; Philippe de Saussure; Philippe Seksik; Philippe Marteau; Marc Lemann; Jean-Frédéric Colombel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Inflammatory bowel diseases Volume: 15 ISSN: 1536-4844 ISO Abbreviation: Inflamm. Bowel Dis. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-16 Completed Date: 2009-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508162 Medline TA: Inflamm Bowel Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1044-8 Citation Subset: IM |
Affiliation:
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Service des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Huriez, CHU Lille, Lille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Colitis, Ulcerative / drug therapy* Cyclosporine / administration & dosage*, adverse effects Drug Resistance Female Follow-Up Studies Humans Immunosuppressive Agents / administration & dosage*, adverse effects Pregnancy Pregnancy Complications / drug therapy* Pregnancy Outcome* Retrospective Studies Severity of Illness Index Steroids / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/Steroids; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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