Document Detail


Cyclosporine in the treatment of psoriatic arthritis.
MedLine Citation:
PMID:  2930208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The short-term efficacy of cyclosporine in the treatment of six patients with moderately severe to severe psoriatic arthritis was evaluated in an open study. Patients received oral cyclosporine (6 mg/kg/d) for eight weeks. In all patients, significant improvement of psoriasis was noted within two to four weeks. At the end of therapy, rheumatologic assessment revealed the following trends in disease activity: a decrease in the number of tender joints, joint tenderness index, duration of morning stiffness, and an increase in grip strength. There was a decrease in the number of swollen joints, joint swelling index, and the time taken to walk 50 ft. Overall disease activity significantly improved as assessed independently by the patient and physician. For psoriasis and psoriatic arthritis, disease activity worsened toward baseline within four weeks of discontinuation of therapy. Short-term, low-dose cyclosporine therapy may be effective in treating psoriasis and psoriatic arthritis.
Authors:
A K Gupta; E L Matteson; C N Ellis; V C Ho; D C Tellner; J J Voorhees; W J McCune
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  125     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-03     Completed Date:  1989-05-03     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-10     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arthritis / blood,  drug therapy*
Cyclosporins / adverse effects,  therapeutic use*
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Humans
Male
Psoriasis / blood,  drug therapy*
Chemical
Reg. No./Substance:
0/Cyclosporins
Comments/Corrections
Comment In:
Arch Dermatol. 1989 Nov;125(11):1582-3   [PMID:  2817922 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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