Document Detail


Cyclosporine in the treatment of membranoproliferative glomerulonephritis.
MedLine Citation:
PMID:  18154419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Therapeutic approach to patients with idiopathic membranoproliferative glomerulonephritis is still controversial. Because it is more common in developing countries, the studies about it are limited.
METHODS: We used cyclosporine to treat 18 patients with membranoproliferative glomerulonephritis who were resistant to other treatment protocols such as using aspirin, dipyridamole, or steroids. All patients were treated with cyclosporine plus low-dose prednisone and were followed for an average 108 weeks.
RESULTS: Partial or complete remission of proteinuria occurred in 94% of the patients (P<0.01). Relapse occurred in one (14.2%) of remitters after discontinuation of the drug. But the remainder stayed in remission to the end of the observation period. There was a 507% decrease in the baseline creatinine clearance in one patient (5.5%).
CONCLUSION: These results suggest that cyclosporine may be an effective therapeutic agent in the treatment of resistant idiopathic membranoproliferative glomerulonephritis. Although the response is appeared later than other types of glomerulonephritis, but a long-term decrease in proteinuria and preservation of filtration function were observed in a significant proportion of the treated patients.
Authors:
Nazila Bagheri; Eghlim Nemati; Khosro Rahbar; Ali Nobakht; Behzad Einollahi; Saeed Taheri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  11     ISSN:  1029-2977     ISO Abbreviation:  Arch Iran Med     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-06-03     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Taleghani Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. nbagheri@sbmu.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cyclosporine / therapeutic use*
Female
Glomerulonephritis, Membranoproliferative / diagnosis,  drug therapy*
Humans
Immunosuppressive Agents / therapeutic use*
Male
Middle Aged
Treatment Outcome
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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