| Cyclosporine for SJS/TEN: a case series and review of the literature. | |
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MedLine Citation:
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PMID: 21323097 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Clear guidelines for the treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are lacking due to its infrequency and the absence of large controlled studies. Systemic corticosteroids and intravenous immunoglobulin (IVIG) have received considerable attention, though reports of the use of these agents have demonstrated mixed success rates in improving morbidity and mortality from SJS/TEN. We present a case series of 4 patients with SJS/TEN who rapidly responded to treatment with cyclosporin A (CsA). We discuss the proposed mechanism of action and the rationale for the use of cyclosporin based on the currently understood pathophysiologic mechanism of TEN. |
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Authors:
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Drew Reese; J Scott Henning; Kyle Rockers; Denise Ladd; Robert Gilson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cutis; cutaneous medicine for the practitioner Volume: 87 ISSN: 0011-4162 ISO Abbreviation: Cutis Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006440 Medline TA: Cutis Country: United States |
Other Details:
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Languages: eng Pagination: 24-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Wilford Hall Medical Center, Lackland Air Force Base, Texas, USA. drew.reese@amedd.army.mil |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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