Document Detail


Cyclosporine A alleviates severe anaemia associated with refractory large granular lymphocytic leukaemia and chronic natural killer cell lymphocytosis.
MedLine Citation:
PMID:  8639439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Large granular lymphocytic (LGL) leukaemia and chronic natural killer cell lymphocytosis (CNKL) are chronic indolent disorders often associated with neutropenia and constitutional symptoms. Severe anaemia occurs in about 20% of patients and is currently treated with corticosteroids followed by oral cyclophosphamide in non-responders. 30% of patients fail initial measures, and salvage therapy is inadequate. We describe three transfusion-dependent patients (two with T-LGL leukaemia, one with CNKL) refractory to corticosteroids, cyclophosphamide, and in one case fludarabine. Cyclosporine A (CSA) initiation resulted in prompt transfusion-independence and was well tolerated in all patients, making it an attractive alternative therapy for this disorder.
Authors:
K C Bible; A Tefferi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  93     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-15     Completed Date:  1996-07-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  406-8     Citation Subset:  IM    
Affiliation:
Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anemia / drug therapy*,  etiology
Chronic Disease
Cyclosporine / therapeutic use*
Dose-Response Relationship, Drug
Humans
Killer Cells, Natural / pathology
Leukemia, T-Cell / complications*
Lymphocytosis / complications,  drug therapy*
Male
Middle Aged
Chemical
Reg. No./Substance:
59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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