| Cyclosporine A alleviates severe anaemia associated with refractory large granular lymphocytic leukaemia and chronic natural killer cell lymphocytosis. | |
| | |
MedLine Citation:
|
PMID: 8639439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Large granular lymphocytic (LGL) leukaemia and chronic natural killer cell lymphocytosis (CNKL) are chronic indolent disorders often associated with neutropenia and constitutional symptoms. Severe anaemia occurs in about 20% of patients and is currently treated with corticosteroids followed by oral cyclophosphamide in non-responders. 30% of patients fail initial measures, and salvage therapy is inadequate. We describe three transfusion-dependent patients (two with T-LGL leukaemia, one with CNKL) refractory to corticosteroids, cyclophosphamide, and in one case fludarabine. Cyclosporine A (CSA) initiation resulted in prompt transfusion-independence and was well tolerated in all patients, making it an attractive alternative therapy for this disorder. |
| | |
Authors:
|
K C Bible; A Tefferi |
Related Documents
:
|
1415189 - Pseudoxanthoma elasticum-like skin lesions and angioid streaks in beta-thalassemia. 7446549 - The liver in sickle cell disease. a clinicopathologic study of 70 patients. 21278619 - Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and pr... 3830529 - Hypersplenism and splenectomy in lymphoproliferative and myeloproliferative disorders. 8184139 - The anemia of acute renal failure: association with oliguria and elevated blood urea. 3002959 - Heterogeneity of haplotypes among patients with severe cooley disease in eastern sicily. 4057449 - Laboratory evaluation of patients with vascular occlusive disease. 21112439 - Electrodiagnostic findings and surgical outcome in isolated first branch lateral planta... 16034449 - The prevalence of hypertension and its association with other cardiovascular disease ri... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: British journal of haematology Volume: 93 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1996 May |
Date Detail:
|
Created Date: 1996-07-15 Completed Date: 1996-07-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 406-8 Citation Subset: IM |
Affiliation:
|
Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anemia / drug therapy*, etiology Chronic Disease Cyclosporine / therapeutic use* Dose-Response Relationship, Drug Humans Killer Cells, Natural / pathology Leukemia, T-Cell / complications* Lymphocytosis / complications, drug therapy* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: BCR rearrangement without juxtaposition of ABL in pre-T acute lymphoblastic leukaemia.
Next Document: 2-Chlorodeoxyadenosine in the treatment of hairy cell leukaemia: differences in response in patients...