Document Detail

Cyclosporin A induces peritoneal fibrosis and angiogenesis during chronic peritoneal exposure to a glucose-based, lactate-buffered dialysis solution in the rat.
MedLine Citation:
PMID:  18087149     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Cyclosporin A (CsA) stimulates the development of fibrosis. We investigated whether CsA contributes to peritoneal alterations induced by long-term exposure to dialysis solutions. METHODS: Ten rats received peritoneal infusion of dialysis solution and oral CsA for 8 weeks. Eight received only the dialysis solution (controls). Peritoneal function was assessed at 8 weeks followed by sacrifice. The number of vessels was counted, fibrosis was assessed and hydroxyproline was determined. PCR was performed for vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF) and transforming growth factor-beta (TGF-beta). RESULTS: Histology revealed more fibrosis, hydroxyproline and vessels (thick walled) in CsA-exposed animals. Peritoneal transport was not different. The mRNA content of TGF-beta, CTGF and VEGF was higher in CsA. CONCLUSION: CsA combined with exposure to dialysis solutions was associated with increased peritoneal fibrosis and angiogenesis.
Roos van Westrhenen; Jan Aten; Najat Hajji; Onno J de Boer; Cindy Kunne; Dirk R de Waart; Raymond T Krediet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-14
Journal Detail:
Title:  Blood purification     Volume:  25     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  466-72     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Department of Nephrology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Cyclosporine / adverse effects*
Fibrosis / chemically induced*
Glucose / therapeutic use
Hemodialysis Solutions / adverse effects*,  chemistry
Lactic Acid / therapeutic use
Neovascularization, Pathologic / chemically induced*
Peritoneal Dialysis / adverse effects*
Peritoneal Diseases / chemically induced*,  pathology
Rats, Wistar
Reg. No./Substance:
0/Hemodialysis Solutions; 50-21-5/Lactic Acid; 50-99-7/Glucose; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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