| Cyclosporin-A induced posterior reversible encephalopathy syndrome. | |
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MedLine Citation:
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PMID: 18445907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Posterior reversible encephalopathy syndrome (PRES) is a recently proposed clinico-neuroradiological entity observed in a variety of clinical settings such as cyclosporin A (CsA) neurotoxicity. We report a 3.5-year-old Syrian boy in whom steroid-resistant focal segmental glomerulosclerosis (FSGS) was recently diagnosed. The patient remitted his nephrotic syndrome after 10 days of CsA administration. However, he shortly developed altered mental status, visual impairment, focal neurological deficits and seizures. We discontinued CsA that resulted in complete reversal of the patient's encephalopathical condition over a period of 4 months. We conclude that PRES should be suspected in immunosuppresed patients with kidney disease if they have a sudden episode of neurological symptoms. |
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Authors:
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Bassam Saeed; Najat Abou-Zor; Ziad Amer; Issam Kanani; Mahmoud Hilal |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia Volume: 19 ISSN: 1319-2442 ISO Abbreviation: Saudi J Kidney Dis Transpl Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-30 Completed Date: 2008-11-14 Revised Date: 2010-10-28 |
Medline Journal Info:
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Nlm Unique ID: 9436968 Medline TA: Saudi J Kidney Dis Transpl Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 439-42 Citation Subset: IM |
Affiliation:
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Division of Pediatric Nephrology, Surgical Kidney Hospital, Ibn-Alnafis Medical Complex, Damascus, Syria. bmsaeed2000@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Cyclosporine / adverse effects* Humans Immunosuppressive Agents / adverse effects* Male Posterior Leukoencephalopathy Syndrome / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 59865-13-3/Cyclosporine |
| Comments/Corrections | |
Comment In:
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Saudi J Kidney Dis Transpl. 2010 Sep;21(5):957-8
[PMID:
20814143
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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