Document Detail


Cyclosporin A in experimental trichinosis scanning electron microscopic study.
MedLine Citation:
PMID:  1431295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The surface morphology of adult and larvae of Trichinella spiralis after cyclosporin A treatment was studied by scanning electron microscopy (SEM) of fixed, dried and metal coated specimens. The earliest topographic changes revealed in adults after the drug treatment were in form of disorganization of the cuticle especially between the hypodermal pores which appeared somewhat thickened and irregular. Other changes were in form of bullae formation covering the whole width of the adult surface. Other specimens showed wrinkling of the outer layer that was seen later to peel off. In few worms layer outer was damaged releasing some of the internal organs. Smoothing of the cuticle with obliteration of the grooves between the cuticular ridges were observed as the earliest surface larval changes, ulcer formation which was deeply seated was seen in patchy areas in some specimens. The interaction between the parasite surface and the drug is of significant importance as this can throw light on the possibilities of its mode of action.
Authors:
L M Boulos; L M Abu-Samra; M Z el-Azzouni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Egyptian Society of Parasitology     Volume:  22     ISSN:  1110-0583     ISO Abbreviation:  J Egypt Soc Parasitol     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1992-12-22     Completed Date:  1992-12-22     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  8102141     Medline TA:  J Egypt Soc Parasitol     Country:  EGYPT    
Other Details:
Languages:  eng     Pagination:  767-73     Citation Subset:  IM    
Affiliation:
Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cyclosporine / pharmacology,  therapeutic use*
Female
Larva / drug effects,  ultrastructure
Male
Mice
Microscopy, Electron, Scanning
Trichinella spiralis / drug effects*,  ultrastructure
Trichinellosis / drug therapy*
Chemical
Reg. No./Substance:
59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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