Document Detail

Cyclosporin A does not affect the in vitro induction of antigen-specific delayed-type hypersensitivity-mediating T cells.
MedLine Citation:
PMID:  3549328     Owner:  NLM     Status:  MEDLINE    
The effect of cyclosporin A (CsA) on the in vitro induction of sheep red blood cell (SRBC)-specific T cells mediating the delayed-type hypersensitivity (DTH) reaction was studied. CsA (1 microgram/ml) addition to the culture medium totally inhibits the in vitro anti-SRBC humoral response but does not interfere with the generation of anti-SRBC DTH-mediating T (TDTH) cells. The induction of TDTH requires the presence of antigen and their expression is mediated selectively by the antigen used in the culture. The TDTH cells generated are Lyt-1+,2- and their induction occurs with a similar efficiency in CsA-treated and untreated cultures: the frequency of the TDTH cells increases by a factor of 10 to 20 during the 6-day incubation period. Lyt-2+ suppressor cells are also generated in CsA-treated or untreated cultures. Our results suggest that a small fraction of T cells can be driven into the proliferative pathway by antigen even in presence of CsA.
B Shidani; I Motta; P Truffa-Bachi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunology     Volume:  17     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-08     Completed Date:  1987-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  291-4     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Cyclosporins / pharmacology*
Hemolytic Plaque Technique
Hypersensitivity, Delayed*
Mice, Inbred C57BL
T-Lymphocytes / drug effects,  immunology*
Reg. No./Substance:

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