| Cyclosporin A (CyA) in primary Sjögren's syndrome: a double blind study. | |
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MedLine Citation:
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PMID: 3532967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy and toxicity of cyclosporin A (CyA) were studied in a blind fashion in 20 patients with primary Sjögren's syndrome (pSS). The dose of CyA or placebo was 5 mg/kg of body weight daily. Among the 20 patients, 10 received CyA and 10 placebo. The two groups were matched for age, sex, and disease duration. Patients treated with CyA improved in subjective xerostomia in comparison with patients treated with placebo. Subjective xerophthalmia and recurrent parotid gland enlargement did not differ in the two groups. No change in Schirmer's test and stimulated parotid flow rate was observed in either group. In contrast, the histopathological lesion of patients treated with CyA remained unchanged in most of the patients, while in the placebo treated group the lesion deteriorated. Laboratory parameters did not change before or after treatment in either group. The only clinical side effect observed in the CyA treated group was hypertrichosis. |
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Authors:
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A A Drosos; F N Skopouli; J S Costopoulos; C S Papadimitriou; H M Moutsopoulos |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 45 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-11-10 Completed Date: 1986-11-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 732-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Cyclosporins / adverse effects, therapeutic use* Double-Blind Method Female Humans Hypertrichosis / chemically induced Male Middle Aged Random Allocation Salivary Glands, Minor / pathology Sjogren's Syndrome / drug therapy*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Cyclosporins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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