Document Detail

Cyclosporin A (CyA) in primary Sjögren's syndrome: a double blind study.
MedLine Citation:
PMID:  3532967     Owner:  NLM     Status:  MEDLINE    
The efficacy and toxicity of cyclosporin A (CyA) were studied in a blind fashion in 20 patients with primary Sjögren's syndrome (pSS). The dose of CyA or placebo was 5 mg/kg of body weight daily. Among the 20 patients, 10 received CyA and 10 placebo. The two groups were matched for age, sex, and disease duration. Patients treated with CyA improved in subjective xerostomia in comparison with patients treated with placebo. Subjective xerophthalmia and recurrent parotid gland enlargement did not differ in the two groups. No change in Schirmer's test and stimulated parotid flow rate was observed in either group. In contrast, the histopathological lesion of patients treated with CyA remained unchanged in most of the patients, while in the placebo treated group the lesion deteriorated. Laboratory parameters did not change before or after treatment in either group. The only clinical side effect observed in the CyA treated group was hypertrichosis.
A A Drosos; F N Skopouli; J S Costopoulos; C S Papadimitriou; H M Moutsopoulos
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  45     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-11-10     Completed Date:  1986-11-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  732-5     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Cyclosporins / adverse effects,  therapeutic use*
Double-Blind Method
Hypertrichosis / chemically induced
Middle Aged
Random Allocation
Salivary Glands, Minor / pathology
Sjogren's Syndrome / drug therapy*,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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