| Cyclophosphamide in exacerbations of multiple sclerosis. Therapeutic trial and a strategy for pilot drug studies. | |
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MedLine Citation:
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PMID: 1097604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cyclophosphamide (CY) has been shown to reverse the signs of experimental allergic encephalomyelitis (EAE) even after the onset of neurological deficits. Because of the analogy of EAE to exacerbations of multiple sclerosis (MS) a clinical trial of CY in acute MS exacerbations was undertaken. A 'sequential criterion' method was used to minimize the size of sample needed for this pilot study. CY failed to alter significantly the course of acute exacerbations of MS. Possible reasons for this failure, and the value of the sequential criterion method in pilot studies, are discussed. |
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Authors:
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D A Drachman; P Y Paterson; R T Schmidt; R F Spehlmann |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 38 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1975 Jun |
Date Detail:
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Created Date: 1975-10-21 Completed Date: 1975-10-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 592-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Alopecia / chemically induced Animals Clinical Trials as Topic Cyclophosphamide / adverse effects, therapeutic use* Cystitis / chemically induced Disease Models, Animal Drug Evaluation Drug Evaluation, Preclinical Encephalomyelitis, Autoimmune, Experimental / drug therapy Female Humans Lymphocyte Activation Male Multiple Sclerosis / drug therapy*, immunology Nausea / chemically induced Pilot Projects Rats |
| Chemical | |
Reg. No./Substance:
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50-18-0/Cyclophosphamide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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