Document Detail

Cyclophosphamide in exacerbations of multiple sclerosis. Therapeutic trial and a strategy for pilot drug studies.
MedLine Citation:
PMID:  1097604     Owner:  NLM     Status:  MEDLINE    
Cyclophosphamide (CY) has been shown to reverse the signs of experimental allergic encephalomyelitis (EAE) even after the onset of neurological deficits. Because of the analogy of EAE to exacerbations of multiple sclerosis (MS) a clinical trial of CY in acute MS exacerbations was undertaken. A 'sequential criterion' method was used to minimize the size of sample needed for this pilot study. CY failed to alter significantly the course of acute exacerbations of MS. Possible reasons for this failure, and the value of the sequential criterion method in pilot studies, are discussed.
D A Drachman; P Y Paterson; R T Schmidt; R F Spehlmann
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  38     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-10-21     Completed Date:  1975-10-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  592-7     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Alopecia / chemically induced
Clinical Trials as Topic
Cyclophosphamide / adverse effects,  therapeutic use*
Cystitis / chemically induced
Disease Models, Animal
Drug Evaluation
Drug Evaluation, Preclinical
Encephalomyelitis, Autoimmune, Experimental / drug therapy
Lymphocyte Activation
Multiple Sclerosis / drug therapy*,  immunology
Nausea / chemically induced
Pilot Projects
Reg. No./Substance:

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