| Cyclophosphamide for anti-GAD antibody-positive refractory status epilepticus. | |
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MedLine Citation:
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PMID: 18177354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glutamic acid decarboxylase (GAD) is the enzyme which catalyzes the production of gamma aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system (CNS). There is increasing evidence that severe GAD autoimmunity may be associated with refractory epilepsy. Immunomodulation and GABAergic drugs have been suggested as treatment options. We report here for the first time on a patient with sudden onset of refractory status epilepticus in the presence of strong intrathecal anti-GAD antibody synthesis who was successfully treated with cyclophosphamide, and give an overview of available data on epilepsy associated with GAD autoimmunity. |
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Authors:
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Ines C Kanter; Hagen B Huttner; Dimitre Staykov; Teresa Biermann; Tobias Struffert; Frank Kerling; Max-Josef Hilz; Peter D Schellinger; Stefan Schwab; Jürgen Bardutzky |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-12-28 |
Journal Detail:
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Title: Epilepsia Volume: 49 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-05 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 914-20 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Erlangen, Erlangen, Germany. ines-christine.kanter@uk-erlangen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Anti-Idiotypic / biosynthesis, drug effects*, immunology Anticonvulsants / therapeutic use Autoimmune Diseases / drug therapy*, immunology Autoimmunity / immunology Brain / pathology, radionuclide imaging Cyclophosphamide / therapeutic use* Drug Resistance Epilepsy, Complex Partial / drug therapy, immunology Female Glutamate Decarboxylase / immunology* Humans Immunosuppressive Agents / administration & dosage, therapeutic use* Injections, Spinal Magnetic Resonance Imaging Status Epilepticus / drug therapy*, immunology*, pathology Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/Anticonvulsants; 0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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