Document Detail

Cyclophilin-40 has a cellular role in the aryl hydrocarbon receptor signaling.
MedLine Citation:
PMID:  18708059     Owner:  NLM     Status:  MEDLINE    
Cyclophilin-40 (CyP40) promotes the formation of the gel shift complex that contains the aryl hydrocarbon receptor (AhR), AhR nuclear translocator (Arnt) and dioxin response element (DRE) using baculovirus expressed proteins. Here we reported that CyP40 plays a role in the AhR signaling. When the CyP40 content in MCF-7 cells is reduced, up-regulation of cyp1a1 and cyp1b1 by 3-methylchloranthrene (3MC) is also reduced, suggesting that CyP40 is essential for maximal AhR function. The CyP40 region containing amino acids 186-215, but not the peptidyl-prolyl cis-trans isomerase and tetratricopeptide repeat domains, is essential for forming the AhR/Arnt/DRE complex. CyP40 is found in the cell nucleus after 3MC treatment and appears to promote the DRE binding form of the AhR/Arnt heterodimer.
Tony C Luu; Pompeya Bhattacharya; William K Chan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-08-15
Journal Detail:
Title:  FEBS letters     Volume:  582     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-11-13     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3167-73     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Aryl Hydrocarbon Hydroxylases / genetics
Aryl Hydrocarbon Receptor Nuclear Translocator / metabolism*
Cell Line, Tumor
Cell Nucleus / metabolism
Cyclophilins / genetics,  metabolism*
Cytochrome P-450 CYP1A1 / genetics
Dioxins / pharmacology
Electrophoretic Mobility Shift Assay
Methylcholanthrene / pharmacology
Receptors, Aryl Hydrocarbon / metabolism*
Response Elements / drug effects
Signal Transduction
Grant Support
Reg. No./Substance:
0/Dioxins; 0/Receptors, Aryl Hydrocarbon; 138391-32-9/Aryl Hydrocarbon Receptor Nuclear Translocator; 56-49-5/Methylcholanthrene; EC Hydrocarbon Hydroxylases; EC P-450 CYP1A1; EC P-450 CYP1B1; EC 5.2.1.-/Cyclophilins; EC D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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