Document Detail


Cyclopentadiene-Phosphine/Palladium Catalyzed Cleavage of C-N Bonds in Secondary Amines: Synthesis of Pyrrole and Indole Derivatives from Secondary Amines and Alkenyl or Aryldibromides.
MedLine Citation:
PMID:  23198876     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
An efficient Pd-catalyzed cleavage of C(sp3)-N bonds in secondary amines and consequent C(sp2)-N and C(sp3)-N coupling process was developed. Various secondary amines could be used to react with alkenyl or aryl dibromides affording pyrroles and indoles in high yields. Cyclopentadiene-phosphine ligands, a new type of P-olefin ligands, were found to be able to remarkably promote the efficiency of this Pd-catalyzed process. A reactive Pd complex coordinated with a cyclopentadiene-phosphine ligand was successfully isolated and structurally characterized.
Authors:
Weizhi Geng; Wen-Xiong Zhang; Wei Hao; Zhenfeng Xi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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