| Cyclopentadiene-Phosphine/Palladium Catalyzed Cleavage of C-N Bonds in Secondary Amines: Synthesis of Pyrrole and Indole Derivatives from Secondary Amines and Alkenyl or Aryldibromides. | |
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MedLine Citation:
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PMID: 23198876 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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An efficient Pd-catalyzed cleavage of C(sp3)-N bonds in secondary amines and consequent C(sp2)-N and C(sp3)-N coupling process was developed. Various secondary amines could be used to react with alkenyl or aryl dibromides affording pyrroles and indoles in high yields. Cyclopentadiene-phosphine ligands, a new type of P-olefin ligands, were found to be able to remarkably promote the efficiency of this Pd-catalyzed process. A reactive Pd complex coordinated with a cyclopentadiene-phosphine ligand was successfully isolated and structurally characterized. |
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Authors:
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Weizhi Geng; Wen-Xiong Zhang; Wei Hao; Zhenfeng Xi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-3 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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