Document Detail


Cyclooxygenase inhibition potentiates myogenic activity in skeletal muscle arterioles.
MedLine Citation:
PMID:  2105665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The proposition that arteriolar constriction to increased intravascular pressure is mediated through either the increased local production of an eicosanoid constrictor factor or decreased production of a dilating factor was examined. The myogenic response of arterioles was studied by enclosing anesthetized rats in an airtight Plexiglas box with the cremaster muscle exteriorized into a tissue bath containing Krebs solution. Microvascular responses were observed by video microscopy. The arteriolar response to a 20-mmHg increase in intravascular pressure was examined in the absence or presence of cyclooxygenase inhibition. In the absence of cyclooxygenase inhibition, second-order arterioles (2As) responded passively to increased pressure by distending to 107 +/- 1% of control diameter. In the presence of the indomethacin, 2As constricted to 79 +/- 5% of control. Third-order arterioles (3As) constricted to 47 +/- 8% of control without indomethacin and similarly to 33 +/- 4% with indomethacin. To test whether inhibitors of endothelium-derived relaxation factor would potentiate the myogenic response of 3As, methylene blue or gossypol was topically applied to the cremaster muscle. Neither inhibitor was found to augment the myogenic vasoconstriction; however, these inhibitors were observed to significantly reduce basal vascular tone. In comparison, the tonic local production of dilating prostaglandins appears to attenuate myogenic activity as demonstrated by the appearance of myogenic activity in the normally passive 2As when exposed to cyclooxygenase inhibitors.
Authors:
M A Hill; M J Davis; G A Meininger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-05     Completed Date:  1990-03-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H127-33     Citation Subset:  IM    
Affiliation:
Department of Medical Physiology, College of Medicine, Texas A&M University, College Station 77843.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / physiology*
Arterioles / drug effects,  physiology*
Cyclooxygenase Inhibitors*
Gossypol / pharmacology
Indomethacin / pharmacology
Male
Mefenamic Acid / pharmacology
Methylene Blue / pharmacology
Muscle Development
Muscles / blood supply*
Nitric Oxide / antagonists & inhibitors
Rats
Rats, Inbred Strains
Vasoconstriction
Grant Support
ID/Acronym/Agency:
HL-33324/HL/NHLBI NIH HHS; HL-38104/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 10102-43-9/Nitric Oxide; 303-45-7/Gossypol; 53-86-1/Indomethacin; 61-68-7/Mefenamic Acid; 61-73-4/Methylene Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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