| Cyclooxygenase inhibition in the dorsal vagal complex of the rat evokes increases in gastric motor function. | |
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MedLine Citation:
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PMID: 9403796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To characterize the involvement of brainstem cyclooxygenase (COX) in the vagal control of gastric motor function, tolmetin, a reversible COX inhibitor, was applied to the surface of the dorsal medulla oblongata or microinjected into the dorsal vagal complex (DVC) in alpha-chloralose anesthetized rats, while intragastric pressure and contractile activity of the pyloric circular and greater curvature longitudinal muscle were monitored. Tolmetin, applied to the surface of the medulla oblongata, increased intragastric pressure and stimulated contractile activity of gastric smooth muscle. Comparable gastric motor effects were observed after microinjection of tolmetin into the DVC. All the effects of tolmetin were abolished by bilateral vagotomy at the midcervical level. These results demonstrate for the first time that COX inhibition evokes vagally-mediated gastric motor effects in the DVC of the rat and support a role for COX products in gastrointestinal regulation. |
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Authors:
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Z K Krowicki; N A Nathan; P J Hornby |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of physiology, Paris Volume: 91 ISSN: 0928-4257 ISO Abbreviation: J. Physiol. Paris Publication Date: 1997 May-Oct |
Date Detail:
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Created Date: 1998-02-17 Completed Date: 1998-02-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9309351 Medline TA: J Physiol Paris Country: FRANCE |
Other Details:
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Languages: eng Pagination: 209-13 Citation Subset: IM |
Affiliation:
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Louisiana State University Medical Center, Department of Pharmacology and Experimental Therapeutics, New Orleans 70112, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Cyclooxygenase Inhibitors / administration & dosage, pharmacology* Gastrointestinal Motility / drug effects* Male Medulla Oblongata / drug effects, physiology Microinjections Rats Rats, Sprague-Dawley Tolmetin / pharmacology Vagotomy Vagus Nerve / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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DK-42714/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 26171-23-3/Tolmetin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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