Document Detail

Cyclooxygenase inhibition improves endothelium-dependent vasodilatation in patients with chronic renal failure.
MedLine Citation:
PMID:  12454227     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Some studies have demonstrated beneficial effects of L-arginine as a substrate for nitric oxide synthesis, and diclofenac as an inhibitor of cyclooxygenase (COX)-derived vasoconstrictive agents on vascular responses in humans during several pathological conditions. The aim of the present study was to investigate the acute effects of L-arginine and diclofenac on endothelium-dependent vasodilatation (EDV) and endothelium-independent vasodilatation (EIDV) in patients with chronic renal failure (CRF). METHODS: Effects of L-arginine and diclofenac on EDV and EIDV were measured in 15 patients with CRF and in 15 healthy controls by means of forearm blood flow measurements with venous occlusion plethysmography during local intra-arterial infusions of methacholine (2 and 4 micro g/min evaluating EDV) and sodium nitroprusside (5 and 10 micro g/min evaluating EIDV). RESULTS: L-Arginine infusion increased methacholine-induced vasodilatation both in patients with CRF and healthy controls. Diclofenac infusion increased methacholine-induced vasodilatation only in patients with CRF. There was no significant change in nitroprusside-induced vasodilatation after L-arginine and diclofenac infusions both in patients with CRF and healthy controls. CONCLUSIONS: These results suggest that COX inhibition reduces the levels of a prostanoid-derived vasoconstrictive agent contributing to the impaired EDV in patients with CRF, while in this age group L-arginine improves EDV regardless of renal function.
Margus Annuk; Bengt Fellström; Lars Lind
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  17     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-27     Completed Date:  2003-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  2159-63     Citation Subset:  IM    
Department of Medical Science, University Hospital, Uppsala, Sweden.
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MeSH Terms
Arginine / therapeutic use
Cyclooxygenase Inhibitors / therapeutic use*
Diclofenac / therapeutic use*
Endothelium, Vascular / physiopathology*
Forearm / blood supply
Kidney Failure, Chronic / drug therapy*,  physiopathology*
Methacholine Chloride / diagnostic use
Middle Aged
Nitroprusside / diagnostic use
Regional Blood Flow / drug effects
Vasodilation / drug effects*
Vasodilator Agents / diagnostic use
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 15307-86-5/Diclofenac; 62-51-1/Methacholine Chloride; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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