| Cyclooxygenase-2 expression in skeletal muscle of knockout mice suffering Duchenne muscular dystrophy. | |
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MedLine Citation:
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PMID: 23188550 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of the present study was to investigate the role of cyclooxygenase-2 (COX-2) expression in fibrotic lesion in mdx mice. A total of six male C57BL/10 mice and six C57BL/10-DMD/mdx were distributed into two groups: control and animals with Duchenne muscular dystrophy (DMD). The medial part of gastrocnemius muscle was evaluated being the specimens stained with hematoxylin and eosin (H&E) and Sirius Red under normal and polarized light to differentiate type I (red and yellow) and III (green) collagen. COX-2 expression was assessed by immunohistochemistry. The results revealed histopathological changes in C57BL/10-DMD/mdx as depicted by regenerating fibers. Sirius Red stain showed a substantial increase in the amount of type I collagen of mdx mice. DMD induced a strong COX-2 immunoexpression in intercellular space. Taken together, our results are consistent with the notion that necrotic and fibrotic lesions are able to increase COX-2 expression in DMD. |
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Authors:
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De Oliveira Flavia; Hananiah Tardivo Quintana; Jeferson André Bortolin; Odair Alfredo Gomes; Edson Aparecido Liberti; Daniel Araki Ribeiro |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-28 |
Journal Detail:
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Title: Histochemistry and cell biology Volume: - ISSN: 1432-119X ISO Abbreviation: Histochem. Cell Biol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506663 Medline TA: Histochem Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biosciences, Federal University of São Paulo, UNIFESP, Av Ana Costa 95, Vila Mathias, Santos, SP, 11060-001, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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