| Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours. | |
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MedLine Citation:
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PMID: 19925514 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: Cyclooxygenase-2 (COX-2) is an enzyme involved in neoplastic processes. The purpose of the present study is to investigate COX-2 expression in the normal human eye and the expression pattern in selected eye tumours involving COX-2 expressing cells. Methods: Immunohistochemical staining using antibodies against COX-2 was performed on paraffin sections of normal human eyes and selected eye tumours arising from cells expressing COX-2. Results: Cyclooxygenase-2 expression was found in various structures of the normal eye. Abundant expression was seen in the cornea, iris, ciliary body and retina. The COX-2 expression was less in tumours deriving from the ciliary epithelium and also in retinoblastoma. Conclusion: Cyclooxygenase-2 is constitutively expressed in normal human eyes. The expression of COX-2 is much lower in selected eye tumours involving COX-2 expressing cells. |
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Authors:
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Jinmei Wang; Yazhen Wu; Steffen Heegaard; Miriam Kolko |
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Publication Detail:
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Type: Journal Article Date: 2009-11-19 |
Journal Detail:
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Title: Acta ophthalmologica Volume: 89 ISSN: 1755-3768 ISO Abbreviation: Acta Ophthalmol Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101468102 Medline TA: Acta Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 681-5 Citation Subset: IM |
Copyright Information:
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© 2009 The Authors. Journal compilation © 2009 Acta Ophthalmol. |
Affiliation:
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Institute of Neuroscience and Pharmacology, Eye Pathology Section, University of Copenhagen, Copenhagen, Denmark Institute of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark Department of Ophthalmology, Second Clinical Hospital, Jilin University, Changchun, Jilin, China Glostrup University Hospital, Department of Ophthalmology, Copenhagen, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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