| Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathways in gastric carcinogenesis. | |
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MedLine Citation:
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PMID: 12592098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Cyclooxygenase-2 (COX-2) expression appears to be increased in several different types of human cancers, suggesting that the presence of COX-2 is associated with carcinogenesis. Recently, increased expression of COX-2 has been frequently detected in gastric cancer, and this may have prognostic significance. In the present study, we aimed to analyze the expression of COX-2 in a much larger sample to determine whether COX-2 expression is related to the clinicopathological features and survival rates of patients with gastric cancer. METHODS: We investigated 140 patients with gastric cancer who underwent surgery between January 1992 and December 1993 and examined the expression of COX-2 in human gastric cancer tissue by immunohistochemistry. RESULTS: COX-2 expression was present in the cytoplasm of tumor cells but not in normal gastric epithelia. Positive expression of COX-2 was detected in 86 of 140 gastric cancers analyzed (61.4%). Positive expression of COX-2 correlated with the depth of tumor invasion (p = 0.015). However, there was no association between COX-2 expression and tumor stage or status of lymph node or distant metastasis. Furthermore, COX-2 expression was not associated with patient survival (p = 0.816). Positive expression of COX-2 occurred more frequently in intestinal than in diffuse or mixed types of cancer and correlated with tumor differentiation (p < 0.001, p = 0.001, respectively). CONCLUSION: These results suggest that COX-2 may play an important role in the evolution of gastric carcinogenesis and be associated with well-differentiated and intestinal type pathways in gastric carcinogenesis. However, COX-2 expression seems to be less useful for establishing prognosis for gastric cancer. |
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Authors:
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Young-Eun Joo; Won-Tae Oh; Jong-Sun Rew; Chang-Soo Park; Sung-Kyu Choi; Sei-Jong Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestion Volume: 66 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 2002 |
Date Detail:
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Created Date: 2003-02-19 Completed Date: 2003-05-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: Switzerland |
Other Details:
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Languages: eng Pagination: 222-9 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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enzymology,
mortality,
pathology*,
secondary Adult Aged Cyclooxygenase 2 Cytoplasm / enzymology Female Gastric Mucosa / enzymology Humans Immunohistochemistry Isoenzymes / analysis* Lymphatic Metastasis Male Membrane Proteins Middle Aged Prognosis Prostaglandin-Endoperoxide Synthases / analysis* Stomach Neoplasms / enzymology, mortality, pathology* Survival Rate Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; 0/Membrane Proteins; 0/Tumor Markers, Biological; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
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