| The Cyclooxygenase-1 C50T Polymorphism Is Not Associated with Aspirin Responsiveness Status in Stable Coronary Artery Disease Tunisian Patients. | |
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MedLine Citation:
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PMID: 21434767 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study, we evaluate the relationships between aspirin nonresponsiveness and the cyclooxygenase-1 (Cox-1) gene C50T polymorphism in stable coronary artery disease (CAD) Tunisian patients. One hundred twenty-five stable CAD patients were included. The Cox-1 gene C50T polymorphism was determined by the polymerase chain reaction/restriction fragment length polymorphism method. Aspirin response was evaluated by measuring the collagen epinephrine closer time and the urinary dehydro-thromboxane B2 excretion. According to the collagen epinephrine closer time values, the frequency of the -50T allele was not significantly different in bad responders when compared with good responders (36.8% vs. 15.7%; p=0.1). Similarly, the presence of the -50T mutant allele was not statistically different comparing bad and good responders according to the urinary 11-dehydro-thromboxane B2 excretion concentration (60% vs. 40%; p=0.43). Our study did not demonstrate any association between the Cox-1 gene C50T polymorphism and aspirin nonresponsiveness status in stable CAD patients. |
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Authors:
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Tahar Chakroun; Faouzi Addad; Saloua Yacoub; Fatma Abderrezak; Gregoris T Gerotziafas; Sadia Abdelkafi; Mohssen Hassine; Habib Gamra; Mohamed Hatmi; Ismail Elalamy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-24 |
Journal Detail:
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Title: Genetic testing and molecular biomarkers Volume: - ISSN: 1945-0257 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101494210 Medline TA: Genet Test Mol Biomarkers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Regional Center of Blood Transfusion, Research Unit "Platelet function Study" UR.06SP05, Farhat Hached University Hospital , Sousse, Tunisia . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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