Document Detail


Cycloheximide blocks the toxic effect of streptomycin in guinea pig vestibular hair cells.
MedLine Citation:
PMID:  9879399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apoptosis has been suggested to be a predominant cell death process for streptomycin-induced degeneration of vestibular hair cells. However, the biochemical aspects of this have not been studied. The purpose of this study was to examine the biochemical aspects of apoptosis of vestibular hair cells caused by streptomycin. Cycloheximide is a widely used protein synthesis inhibitor in studies of apoptosis. We therefore investigated cycloheximide effects on degeneration of vestibular hair cells following streptomycin applications. Supplements of cycloheximide significantly prevented DNA fragmentation in hair cell nuclei and reduced the loss of hair cells. This suggests that cycloheximide possibly inhibits apoptosis of hair cells and attenuates streptomycin-induced degeneration of the vestibular epithelium.
Authors:
T Nakagawa; H Yamane; M Takayama; K Sunami; Y Nakai
Related Documents :
16377109 - 2,3-dihydroxybenzoic acid attenuates kanamycin-induced volume reduction in mouse utricu...
20478259 - Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells.
2184039 - Distribution of peroxisomes and glycolate metabolism in relation to calcium oxalate for...
7506249 - Electron-probe analysis of isolated goldfish hair cells: implications for preparing hea...
18157569 - Sox2 and jagged1 expression in normal and drug-damaged adult mouse inner ear.
9879399 - Cycloheximide blocks the toxic effect of streptomycin in guinea pig vestibular hair cells.
23203049 - Profound re-organization of cell surface proteome in equine retinal pigment epithelial ...
599169 - Tissue economics of hydra: regulation of cell cycle, animal size and development by con...
12202429 - Cytogenetic analysis of giant oocytes and zygotes to assess their relevance for the dev...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica. Supplementum     Volume:  538     ISSN:  0365-5237     ISO Abbreviation:  Acta Otolaryngol Suppl     Publication Date:  1998  
Date Detail:
Created Date:  1999-03-18     Completed Date:  1999-03-18     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0370355     Medline TA:  Acta Otolaryngol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  36-9     Citation Subset:  IM; S    
Affiliation:
Department of Otorhinolaryngology, Yodogawa Christian Hospital, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / toxicity*
Apoptosis / drug effects
Cycloheximide / pharmacology*
Guinea Pigs
Hair Cells, Vestibular / drug effects*
In Situ Nick-End Labeling
Protein Synthesis Inhibitors / pharmacology*
Streptomycin / toxicity*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Protein Synthesis Inhibitors; 57-92-1/Streptomycin; 66-81-9/Cycloheximide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Time-dependent response of vestibular hair cells of guinea pigs following high-dose applications of ...
Next Document:  Local substances regulating cochlear blood flow.