Document Detail

Cycloheximide blocks the toxic effect of streptomycin in guinea pig vestibular hair cells.
MedLine Citation:
PMID:  9879399     Owner:  NLM     Status:  MEDLINE    
Apoptosis has been suggested to be a predominant cell death process for streptomycin-induced degeneration of vestibular hair cells. However, the biochemical aspects of this have not been studied. The purpose of this study was to examine the biochemical aspects of apoptosis of vestibular hair cells caused by streptomycin. Cycloheximide is a widely used protein synthesis inhibitor in studies of apoptosis. We therefore investigated cycloheximide effects on degeneration of vestibular hair cells following streptomycin applications. Supplements of cycloheximide significantly prevented DNA fragmentation in hair cell nuclei and reduced the loss of hair cells. This suggests that cycloheximide possibly inhibits apoptosis of hair cells and attenuates streptomycin-induced degeneration of the vestibular epithelium.
T Nakagawa; H Yamane; M Takayama; K Sunami; Y Nakai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica. Supplementum     Volume:  538     ISSN:  0365-5237     ISO Abbreviation:  Acta Otolaryngol Suppl     Publication Date:  1998  
Date Detail:
Created Date:  1999-03-18     Completed Date:  1999-03-18     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0370355     Medline TA:  Acta Otolaryngol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  36-9     Citation Subset:  IM; S    
Department of Otorhinolaryngology, Yodogawa Christian Hospital, Osaka, Japan.
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MeSH Terms
Anti-Bacterial Agents / toxicity*
Apoptosis / drug effects
Cycloheximide / pharmacology*
Guinea Pigs
Hair Cells, Vestibular / drug effects*
In Situ Nick-End Labeling
Protein Synthesis Inhibitors / pharmacology*
Streptomycin / toxicity*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Protein Synthesis Inhibitors; 57-92-1/Streptomycin; 66-81-9/Cycloheximide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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