Document Detail


Cyclodextrin-poly(anhydride) nanoparticles as new vehicles for oral drug delivery.
MedLine Citation:
PMID:  21463219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The oral administration of drugs belonging to Class IV of the Biopharmaceutical Classification System (BCS) represents a major challenge. These drugs display poor aqueous solubility and specific permeability characteristics. Most of these compounds are substrates of the P-glycoprotein and/or the cytochrome P450. Among other types of drug, various anti-cancer drugs also suffer from these drawbacks (i.e., paclitaxel), which limits the possibilities for developing oral treatments.
AREAS COVERED: This review discusses the factors that influence the bioavailability of drugs when administered by the oral route, as well as the capabilities of cyclodextrins when associated with nanoparticles. In particular, evidence is given regarding the synergistic effect between cyclodextrins and bioadhesive nanoparticles, on the oral delivery of pharmaceuticals.
EXPERT OPINION: This article aims to provide an overview of the multiple gains in incorporating cyclodextrins in poly(anhydride) nanoparticles, including improvement of their bioadhesive capability, the loading of lipophilic drugs and the effect on efflux membrane proteins and cytochrome P450. The combination between bioadhesive nanoparticles and P-gp inhibitors without pharmacological activity (i.e., cyclodextrins) may be useful to promote the oral bioavailability of drugs ascribed to Class IV of the BCS.
Authors:
Maite Agüeros; Socorro Espuelas; Irene Esparza; Patricia Calleja; Ivan Peñuelas; Gilles Ponchel; Juan M Irache
Related Documents :
23620229 - Modelling the regulation of telomere length: the effects of telomerase and g-quadruplex...
21421109 - The use of genomic information to optimize cancer chemotherapy.
23578029 - Medicinal chemistry design principles for liver targeting through oatp transporters.
21427579 - New therapies in the management of rheumatoid arthritis.
21216589 - The acridone derivative mbli-87 sensitizes breast cancer resistance protein-expressing ...
21291399 - The significance of chirality in drug design and development.
12583849 - Hypnotics: an update.
19002789 - Topoisomerase i inhibitors and drug resistance.
2147709 - Lipocortin-1 immunoreactivity in the human pituitary gland.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-04-04
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  8     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-19     Completed Date:  2011-09-16     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  721-34     Citation Subset:  IM    
Affiliation:
University of Navarra, School of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Pamplona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Oral
Animals
Biological Availability
Cyclodextrins / chemistry*,  pharmacokinetics,  pharmacology
Cytochrome P-450 Enzyme System / antagonists & inhibitors
Drug Carriers / chemistry*,  pharmacokinetics,  pharmacology
Humans
Nanoparticles / chemistry*
P-Glycoprotein / antagonists & inhibitors
Paclitaxel / administration & dosage,  chemistry,  pharmacokinetics
Polyanhydrides / chemistry*,  pharmacokinetics,  pharmacology
Solubility
Surface Properties
Tissue Distribution
Chemical
Reg. No./Substance:
0/Cyclodextrins; 0/Drug Carriers; 0/P-Glycoprotein; 0/Polyanhydrides; 33069-62-4/Paclitaxel; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Maxillary incisor root resorption induced by ectopic canines:A follow-up study, 13 to 28 years post...
Next Document:  Outcome of the cementless Taperloc stem: a comprehensive literature review including arthroplasty re...