Document Detail

Cyclins and the cyclin-kinase system--their potential roles in nephrology.
MedLine Citation:
PMID:  9719135     Owner:  NLM     Status:  MEDLINE    
Our understanding of the cell-cycle mechanisms has progressively advanced in the past few years. Cyclins and cyclin-dependent kinases play major roles as positive cell-cycle regulatory proteins and CDK inhibitors; while the Kip family and INK4 family are negative regulatory proteins in mesangial cells and renal tubular cells. An understanding of the cell cycle is essential for the rational design of novel pharmacotherapeutic approaches to suppress the excessive proliferation of mesangial cells in glomerular disease and hypertrophic tubular disease.
Y Terada; S Inoshita; O Nakashima; M Kuwahara; S Sasaki; F Marumo
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Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  13     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-11-06     Completed Date:  1998-11-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1913-6     Citation Subset:  IM    
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MeSH Terms
Cell Cycle / physiology
Cyclin-Dependent Kinases / antagonists & inhibitors,  physiology*
Cyclins / physiology*
Glomerular Mesangium / cytology
Kidney / physiology*
Kidney Diseases / pathology,  physiopathology
Nephrology / methods
Reg. No./Substance:
0/Cyclins; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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