| Cycling through development in Drosophila and other metazoa. | |
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MedLine Citation:
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PMID: 11146648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell-division cycle is an orchestrated sequence of events that results in the duplication of a cell. In metazoa, cell proliferation is regulated in response to differentiation signals and body-size parameters, which either induce cell duplication or arrest the cell cycle, to ensure that organs develop to the correct size. In addition, the cell cycle may be altered to meet specialized requirements. This can be seen in the rapid cleavage cycles of vertebrates and insects that lack gap phases, in the nested S phases of Drosophila, and in the endocycles of nematodes, insects, plants and mammals that lack mitosis. Here we present the various modes of cell-cycle regulation in metazoa and discuss their possible generation by a combination of universally conserved molecules and new regulatory circuits. |
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Authors:
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S J Vidwans; T T Su |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature cell biology Volume: 3 ISSN: 1465-7392 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100890575 Medline TA: Nat Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: E35-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biophysics, University of California at San Francisco, California 94143-0448, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / physiology* Drosophila / cytology, embryology*, genetics Gene Expression Regulation, Developmental / physiology* Genes, cdc / physiology Humans Signal Transduction / genetics Vertebrates / anatomy & histology, embryology*, genetics Yeasts / cytology, genetics, growth & development |
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