Document Detail


Cyclin specificity: how many wheels do you need on a unicycle?
MedLine Citation:
PMID:  11329367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cyclin-dependent kinase (CDK) activity is essential for eukaryotic cell cycle events. Multiple cyclins activate CDKs in all eukaryotes, but it is unclear whether multiple cyclins are really required for cell cycle progression. It has been argued that cyclins may predominantly act as simple enzymatic activators of CDKs; in opposition to this idea, it has been argued that cyclins might target the activated CDK to particular substrates or inhibitors. Such targeting might occur through a combination of factors, including temporal expression, protein associations, and subcellular localization.
Authors:
M E Miller; F R Cross
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cell science     Volume:  114     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-04     Completed Date:  2001-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1811-20     Citation Subset:  IM    
Affiliation:
The Rockefeller University, New York, NY 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / physiology*
Cyclins / metabolism*
Eukaryotic Cells / cytology*,  enzymology
Humans
Phosphorylation
Chemical
Reg. No./Substance:
0/Cyclins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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