| Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup. | |
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MedLine Citation:
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PMID: 18349276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The objective of this study was to determine whether cyclin E overexpression defines an etiologically distinct subgroup of ovarian cancer. METHODS: We analyzed data from 538 epithelial ovarian cancer cases and 629 controls enrolled in a population-based case-control study. Cyclin E protein overexpression was assessed using immunohistochemistry. Case-control and case-case comparisons were done to evaluate the relationship between cyclin E overexpression and epidemiologic risk factors. Logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) while adjusting for potential confounders. RESULTS: Case-control comparisons showed ovarian cancers with and without cyclin E overexpression have different associations with several epidemiologic risk factors. A dose-response relationship was observed between lifetime ovulatory cycles (LOC) and ovarian cancer that overexpressed cyclin E [OR, 1.8; 95% CI, 1.1-3.0 for moderately high LOC (265-390 cycles) and OR, 2.7; 95% CI, 1.6-4.5 for high LOC (>390 cycles) compared with low LOC (<265 cycles)], but no relationship was seen with cancers that lacked overexpression. The most important components of the LOC variable contributing to the differences in the association with the cyclin E subgroups of ovarian cancer were months of oral contraceptive use and months pregnant. CONCLUSIONS: Cyclin E overexpression is associated with a high number of LOC, largely influenced by oral contraceptive use and pregnancy. This suggests that cyclin E overexpression is a molecular signature characteristic of ovarian cancer cases that may arise via a pathway that involves ovulation-induced alterations. |
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Authors:
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Joellen M Schildkraut; Patricia G Moorman; Amy E Bland; Susan Halabi; Brian Calingaert; Regina Whitaker; Paula S Lee; Tyler Elkins-Williams; Rex C Bentley; Jeffrey R Marks; Andrew Berchuck |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 17 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-19 Completed Date: 2008-06-17 Revised Date: 2008-11-25 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 585-93 Citation Subset: IM |
Affiliation:
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Department of Community and Family Medicine, Duke University Medical Center, Box 2949, Durham, NC 27710, USA. schil001@mc.duke.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Chi-Square Distribution Cyclin E / metabolism* Female Humans Immunohistochemistry Middle Aged Neoplasm Staging North Carolina / epidemiology Ovarian Neoplasms / epidemiology, metabolism*, pathology Questionnaires Registries Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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1-R01-CA76016/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cyclin E |
| Comments/Corrections | |
Comment In:
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Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1841; author reply 1841-2
[PMID:
18628442
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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