Document Detail


Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina.
MedLine Citation:
PMID:  22434780     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The cell-cycle regulator Cyclin D1 is expressed in embryonic retinal progenitor cells (RPCs) and regulates their cell-cycle rate and neurogenic output. We report here that Cyclin D1 also has important functions in postnatal retinal histogenesis.
RESULTS: The initial production of Müller glia and bipolar cells was enhanced in Cyclin D1 knockout (Ccnd1(-/-) ) retinas. Despite a steeper than normal rate of depletion of the RPC population at embryonic ages, postnatal Ccnd1(-/-) retinas exhibited an extended window of proliferation, neurogenesis, and gliogenesis. Cyclin D3, normally confined to Müller glia, was prematurely expressed in Ccnd1(-/-) RPCs. However, Cyclin D3 did not compensate for Cyclin D1 in regulating cell-cycle kinetics or neurogenic output.
CONCLUSIONS: The data presented in this study along with our previous finding that Cyclin D2 was unable to completely compensate for the absence of Cyclin D1 indicate that Cyclin D1 regulates retinal histogenesis in ways not shared by the other D-cyclins.
Authors:
Gaurav Das; Anna M Clark; Edward M Levine
Publication Detail:
Type:  Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  241     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-17     Completed Date:  2012-09-20     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  941-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Departments of Ophthalmology and Visual Sciences, and Neurobiology and Anatomy, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / physiology*
Cell Differentiation / physiology*
Cell Proliferation*
Cyclin D1 / genetics*,  metabolism
Cyclin D2 / genetics,  metabolism
Cyclin D3 / genetics,  metabolism
Mice
Mice, Knockout
Retina / cytology,  physiology*
Stem Cells / cytology,  physiology
Grant Support
ID/Acronym/Agency:
P30 EY014800/EY/NEI NIH HHS; R01 EY013760-06/EY/NEI NIH HHS; R01 EY013760-06S1/EY/NEI NIH HHS; R01-EY013760/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Cyclin D2; 0/Cyclin D3; 136601-57-5/Cyclin D1
Comments/Corrections

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