Document Detail

Cyclical estrogen and free radical damage to the rabbit urinary bladder.
MedLine Citation:
PMID:  19956931     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION AND HYPOTHESIS: There are a number of lower urinary tract dysfunctions (LUTD) that occur primarily in women. Our hypothesis is that cyclical estrogen will produce LUTD in part by the generation of free radicals and oxidative damage to cellular and subcellular membranes.
METHODS: Twenty female rabbits were divided into five groups: control, ovariectomized (Ovx), Ovx receiving continuous estrogen, Ovx receiving cyclical estrogen ending off estrogen, and Ovx receiving cyclical estrogen ending on estrogen. Statistical analyses used ANOVA followed by the Tukey analysis for individual differences.
RESULTS: High estrogen increased bladder mass, contraction, compliance, and blood flow and decreased oxidative damage. Low estrogen decreased bladder mass, contraction, compliance, and blood flow and increased oxidative damage.
CONCLUSIONS: The decreased blood flow associated with increased oxidative damage demonstrates that cyclical damage to cellular membranes occurs. This supports the hypothesis that cycling estrogen may play a role in the etiology of LUTD of women.
Alexandra Rehfuss; Catherine Schuler; Christina Maxemous; Robert E Leggett; Robert M Levin
Publication Detail:
Type:  Journal Article     Date:  2009-12-03
Journal Detail:
Title:  International urogynecology journal     Volume:  21     ISSN:  1433-3023     ISO Abbreviation:  Int Urogynecol J     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-08-09     Revised Date:  2011-08-18    
Medline Journal Info:
Nlm Unique ID:  101567041     Medline TA:  Int Urogynecol J     Country:  England    
Other Details:
Languages:  eng     Pagination:  489-94     Citation Subset:  IM    
Albany College of Pharmacy and Health Sciences, 106 New Scotland Ave, Albany, NY 12208, USA.
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MeSH Terms
Dinitrophenols / metabolism
Estrogens / metabolism*
Free Radicals / metabolism*
Muscle Contraction / physiology
Oxidative Stress
Tyrosine / analogs & derivatives,  metabolism
Urinary Bladder / physiology*
Reg. No./Substance:
0/Dinitrophenols; 0/Estrogens; 0/Free Radicals; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine

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