Document Detail


Cyclic phenomena in early myocardial infarction.
MedLine Citation:
PMID:  8835424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been shown by a number of authors that early myocardial infarction constitutes a dynamic process of cyclic oscillation between coronary occlusion and spontaneous coronary reopening. Infarct-markers, such as ST-segment elevation, serum-creatine kinase isoenzyme MB, the atrionatriuretic peptide (ANP) and serum-myoglobin (Mb) exhibit cyclic behaviour pattern during early AMI and thus reflect episodes of intermittent, spontaneous reperfusion. The latter have recently been verified by angiography. The mechanism underlying the phenomena seen in early myocardial infarction is likely to be based on a constant vasoconstrictive stimulus, deriving from aggregating platelets. The vasoconstriction subsequent to platelet aggregation produces an initial episode of myocardial ischemia. This episode is followed by a hypoxia of the artery wall. Reactive coronary dilation secondary to ischemia is than promoted by the release of vasoactive by-products of anaerobic glycolysis as well as changes in the open propability of certain transmembrane ion channels. Thereafter, the initial coronary occlusion is interrupted by transient vasodilation. A wave of reperfusion follows and leads to reoxygenation and wash-out of ischemia-induced vasodilative components as well as biochemical markers. The vasoconstrictive forces then take over again. This results in repeated waves of reperfusion. A number of arguments in favour of this concepts are discussed in this paper.
Authors:
R Gasser; I Schafhalter-Zoppoth; T Schwarz; B Eber; H Köppel; P Lechleitner; B Puschendorf; F Dienstl; W Klein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta medica Austriaca     Volume:  22     ISSN:  0303-8173     ISO Abbreviation:  Acta Med. Austriaca     Publication Date:  1995  
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7501997     Medline TA:  Acta Med Austriaca     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Graz, Austria.
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MeSH Terms
Descriptor/Qualifier:
Atrial Natriuretic Factor / physiology
Coronary Angiography
Coronary Circulation / physiology*
Humans
Myocardial Infarction / physiopathology*
Platelet Activation / physiology*
Vasoconstriction / physiology*
Chemical
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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