Document Detail

Cyclic nucleotides concentrations in the canine heart with regional ischemia. The role of cyclic AMP in ventricular fibrillation and the effect of dibutyryl cyclic AMP.
MedLine Citation:
PMID:  6323779     Owner:  NLM     Status:  MEDLINE    
The effect of the left anterior descending (LAD) coronary artery ligation on myocardial cyclic nucleotides and the role of these nucleotides in the development of ventricular fibrillation (VF) were studied in 135 mongrel dogs by means of sequential punching biopsies from the left ventricle. VF occurred in 50% of the non-premedicated groups. Significant increases of cyclic AMP (c-AMP) concentrations in the ischemic zone were observed after the ligation in VF group. C-AMP concentrations in the ischemic zone were significantly higher after the ligation compared with the border and non-ischemic zone as well as with the non-VF group. They also increased significantly from 30 sec before the onset of VF compared with 2 to 25 min before. No significant change was observed in the control group. In 41 dibutyryl cyclic AMP (DBc-AMP) premedicated dogs, the incidence of VF significantly increased, and c-AMP concentrations were significantly higher than in the non-premedicated group before and after the ligation. They were significantly higher in the ischemic zone 10, 15 and 20 min after the ligation than in the non-ischemic zone. There was a discrepancy of c-AMP concentration between the ischemic zone and the non-ischemic zone in VF induced group, whether DBc-AMP was premedicated or not. Significantly decreased cyclic GMP (c-GMP) levels in the ischemic and the non-ischemic zone were observed after the ligation. C-GMP concentrations with the DBc-AMP premedicated were significantly lower after the ligation compared with the non-premedicated group.(ABSTRACT TRUNCATED AT 250 WORDS)
M Ukai; K Ogawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  48     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-16     Completed Date:  1984-05-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
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MeSH Terms
Bucladesine / pharmacology*
Coronary Disease / metabolism*
Coronary Vessels / surgery
Cyclic AMP / metabolism*
Cyclic GMP / metabolism
Myocardium / metabolism*
Ventricular Fibrillation / etiology,  metabolism*
Reg. No./Substance:
362-74-3/Bucladesine; 60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP

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