Document Detail


Cyclic motility in canine colon: responses to feeding and perfusion.
MedLine Citation:
PMID:  2752869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To further characterize colonic motility in the dog and to examine the effects of intraluminal contents, motor activity in conscious animals was recorded by perfused intraluminal catheters. Animals were studied first with the bowel intact and, later, the colon was fashioned into an isolated loop. In the fasting state, cycles of motility recurred approximately each 30 min. These consisted of sequences of phasic contractions (bursts) that migrated variable distances in either direction; stationary bursts were also recorded. The fasting patterns recorded from intact bowel and isolated loops were not different. Feeding increased colonic motility, and the mean periodicity of cyclic bursts was reduced significantly to approximately 20 min. Moreover, differences were observed between intact bowel and isolated loops in the postprandial period. Diversion of chyme from the colon significantly reduced the motor response to food, but only in the late (2-4 hr) postprandial period, when the less frequent, fasting cycle returned to the loops. Perfusion of isolated loops with chyme or saline reestablished the postprandial pattern seen in intact bowel. The results suggest that the volume, but not the composition, of luminal contents modify postprandial motility in the canine colon. Additional experiments confirmed that, in particular, volatile fatty acids were probably not important determinants of colonic motility in the dog.
Authors:
B Flourie; S Phillips; H Richter; F Azpiroz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  34     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-08-29     Completed Date:  1989-08-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1185-92     Citation Subset:  AIM; IM    
Affiliation:
Gastroenterology Unit, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Descriptor/Qualifier:
Animals
Colon / physiology*
Dogs
Eating*
Fasting
Female
Gastrointestinal Contents
Gastrointestinal Motility*
Perfusion
Pressure
Grant Support
ID/Acronym/Agency:
AM 32121/AM/NIADDK NIH HHS; AM 34988/AM/NIADDK NIH HHS; RR 585/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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