| Cyclic gmp is a measure of physiologic stress. | |
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MedLine Citation:
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PMID: 11491275 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to determine whether patients who were critically ill evidenced elevated levels of blood cyclic guanosine monophosphate (cGMP). Cyclic guanosine monophosphate levels correlated with severity of illness as measured by the APACHE II severity of illness scoring system (p < 0.01). Cyclic guanosine monophosphate also correlated with the level of carboxyhemoglobin (HbCO) (p < 0.001). The correlation between cGMP and creatinine was p < 0.0001. Patients with end-stage disease (renal or liver) tended to have elevated levels of cGMP (p < 0.0001). We conclude that the induction of these two molecules may be linked in patients with increasing severity of illness. |
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Authors:
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K A Hunter; G J Singh; C O Simpkins |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 93 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 2001 Jul-Aug |
Date Detail:
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Created Date: 2001-08-08 Completed Date: 2001-08-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 256-62 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, National Institutes of Health, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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APACHE Adult Aged Biological Markers Carboxyhemoglobin / metabolism Critical Illness Cyclic GMP / blood* Female Humans Kidney Failure, Chronic / metabolism Male Middle Aged Stress, Psychological / blood, diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 7665-99-8/Cyclic GMP; 9061-29-4/Carboxyhemoglobin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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