Document Detail

Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?
MedLine Citation:
PMID:  15063857     Owner:  NLM     Status:  MEDLINE    
The cyclic nucleotide cyclic di-guanosine-monophosphate (c-diGMP) was recognized in the 1980s as a signaling compound that is involved in controlling the condensation of glucose moieties into cellulose polymers. More recent data from several different bacterial species now suggest that c-diGMP might have a general role as secondary messenger in modulating bacterial growth on surfaces by regulating cellular adhesion components and preparing cells for cell-cell and cell-surface interactions.
Urs Jenal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in microbiology     Volume:  7     ISSN:  1369-5274     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
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MeSH Terms
Bacteria / metabolism*
Bacterial Adhesion / physiology
Bacterial Proteins / metabolism
Cyclic GMP / analogs & derivatives*,  metabolism*
Membrane Proteins / metabolism
Second Messenger Systems / physiology*
Reg. No./Substance:
0/Bacterial Proteins; 0/Membrane Proteins; 61093-23-0/bis(3',5')-cyclic diguanylic acid; 7665-99-8/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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