Document Detail


Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe.
MedLine Citation:
PMID:  17602586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bioassay-guided isolation of antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.
Authors:
Elmi N Zainuddin; Renate Mentel; Victor Wray; Rolf Jansen; Manfred Nimtz; Michael Lalk; Sabine Mundt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-28
Journal Detail:
Title:  Journal of natural products     Volume:  70     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1084-8     Citation Subset:  IM    
Affiliation:
Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / chemistry,  isolation & purification*,  pharmacology
Depsipeptides / chemistry,  isolation & purification*,  pharmacology
Germany
Influenza A virus / drug effects*
Inhibitory Concentration 50
Microcystis / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Depsipeptides; 0/ichthyopeptin A; 0/ichthyopeptin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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