| Cyclic adenosine monophosphate induces plasminogen activator inhibitor-1 expression in human mast cells. | |
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MedLine Citation:
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PMID: 20816667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plaminogen activator inhibitor-1 (PAI-1), the key physiological inhibitor of the plasmin fibrinolytic system, plays important roles in the pathogenesis of asthma. Mast cells (MCs) are crucial effector cells and a major source of PAI-1 for asthma. Cyclic adenosine monophosphate (cAMP) is the important regulator of MCs; however, its effects on PAI-1 expression in MCs remain unknown. We reported cAMP/protein kinase A pathway positively regulates PAI-1 expression through cAMP-response element binding protein binding to hypoxia response element-1 at -158 to -153bp of human PAI-1 promoter in human MCs. Moreover, cAMP synergistically augments PAI-1 expression with ionomycin- or IgE receptor cross-linking-mediated stimulation. |
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Authors:
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Zhongcai Ma; Kenny Y C Kwong; Jason P Tovar; David Paek |
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Publication Detail:
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Type: Journal Article Date: 2010-09-08 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 400 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 569-74 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Torrance, CA 90502, USA. zcma@labiomed.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
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genetics,
metabolism* Calcium / metabolism Cells, Cultured Cyclic AMP / metabolism*, pharmacology Cyclic AMP Response Element-Binding Protein / metabolism* Gene Expression Regulation* Humans Mast Cells / metabolism* Plasminogen Activator Inhibitor 1 / genetics* Promoter Regions, Genetic Receptors, IgE / metabolism Response Elements |
| Chemical | |
Reg. No./Substance:
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0/Cyclic AMP Response Element-Binding Protein; 0/Plasminogen Activator Inhibitor 1; 0/Receptors, IgE; 0/SERPINE1 protein, human; 60-92-4/Cyclic AMP; 7440-70-2/Calcium |
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