Document Detail


Cyclic adenosine monophosphate effects on the myocardium: a man who blows hot and cold with one breath.
MedLine Citation:
PMID:  6304177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Agents that increase cellular cyclic adenosine monophosphate (cyclic AMP) levels exert several effects on cardiac function. These include increases in heart rate and both the force of contraction and rate of relaxation. The latter effects, which might appear to be contradictory, actually represent essential components of the response needed to allow the heart to increase its stroke volume when heart rate is accelerated. This article reviews the mechanisms by which cyclic AMP exerts both contraction-promoting and relaxation-promoting effects in the integrated response of the heart to sympathetic stimulation.
Authors:
A M Katz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  2     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  143-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / metabolism
Calcium / metabolism
Calcium-Binding Proteins / metabolism
Cyclic AMP / biosynthesis,  physiology*
Energy Metabolism
Humans
Ion Channels / metabolism
Myocardial Contraction*
Myocardium / metabolism*
Phosphorylation
Protein Kinases / metabolism
Sarcolemma / enzymology
Sarcoplasmic Reticulum / metabolism
Sodium / metabolism
Troponin / metabolism
Troponin I
Grant Support
ID/Acronym/Agency:
HL-21812/HL/NHLBI NIH HHS; HL-22135/HL/NHLBI NIH HHS; HL-26903/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Ion Channels; 0/Troponin; 0/Troponin I; 0/phospholamban; 60-92-4/Cyclic AMP; 7440-23-5/Sodium; 7440-70-2/Calcium; EC 2.7.-/Protein Kinases; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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