Document Detail

Cyclic adenosine 5'-monophosphate in synovial fluid of rheumatoid arthritis and osteoarthritis patients.
MedLine Citation:
PMID:  18695981     Owner:  NLM     Status:  MEDLINE    
The relationship between synovial fluid (SF) cAMP level and IL-18 and PGE2 SF levels in rheumatoid arthritis (RA) and osteoarthritis (OA) patients, and between SF cAMP level and disease as well as inflammatory activity in RA were investigated in 17 RA and 19 OA patients. Erythrocyte sedimentation rate (ESR), serum (S) C-reactive protein (CRP) level and SF IL-18 level were higher in RA than in OA patients. SF PGE2 level was similar in both groups. SF cAMP level was higher in OA than in RA patients. In RA patients, SF cAMP level showed negative correlation with Disease Activity Score including a 28-joint count and S CRP, ESR and SF IL-18 level. The results suggest that cAMP promotes anti-inflammatory response in RA and OA patients, which is higher in the latter. Promotion of anti-inflammatory response by cAMP elevating agents might be useful in the treatment of RA.
Jadranka Morovic-Vergles; Melanie Ivana Culo; Stjepan Gamulin; Filip Culo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-10
Journal Detail:
Title:  Rheumatology international     Volume:  29     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Dubrava University Hospital, and Department of Pathophysiology, Medical School University of Zagreb, Av. G. Suska 6, Zagreb, 10040, Croatia.
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MeSH Terms
Arthritis, Rheumatoid / diagnosis,  metabolism*,  physiopathology
Biological Markers / metabolism
Blood Sedimentation
C-Reactive Protein / analysis
Cyclic AMP / metabolism*
Dinoprostone / metabolism
Health Status
Interleukin-18 / metabolism
Joints / physiopathology
Middle Aged
Osteoarthritis, Knee / diagnosis,  metabolism*,  physiopathology
Severity of Illness Index
Synovial Fluid / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-18; 363-24-6/Dinoprostone; 60-92-4/Cyclic AMP; 9007-41-4/C-Reactive Protein

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