| A Cyclic Peptide mimic of an RNA Recognition Motif of Human La protein is a Potent Inhibitor of Hepatitis C Virus. | |
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MedLine Citation:
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PMID: 23291201 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Due to limited available therapeutic options, developing new lead compounds against hepatitis C virus is an urgent need. Human La protein stimulates hepatitis C virus translation through interaction with the hepatitis C viral RNA. A cyclic peptide mimicking the β-turn of the human La protein that interacts with the viral RNA was synthesized. It inhibits hepatitis C viral RNA translation significantly better than the corresponding linear peptide at longer post-treatment times. The cyclic peptide also inhibited replication as measured by replicon RNA levels using real time RT-PCR. The cyclic peptide emerges as a promising lead compound against hepatitis C. |
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Authors:
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Asit Kumar Manna; Anuj Kumar; Upasana Ray; Saumitra Das; Gautam Basu; Siddhartha Roy |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-2 |
Journal Detail:
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Title: Antiviral research Volume: - ISSN: 1872-9096 ISO Abbreviation: Antiviral Res. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109699 Medline TA: Antiviral Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Division of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata-700 032. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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