| Cyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii. | |
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MedLine Citation:
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PMID: 19201464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular metabolism is required for cell proliferation. However, the way in which metabolic signals are conveyed to cell cycle decisions is unclear. Cyclic ADP-ribose (cADPR), the NAD(+) metabolite, mobilizes calcium from calcium stores in many cells. We found that dinoflagellate cells with higher metabolic rate underwent multiple fission (MF), a division mode in which cells can exceed twice their sizes at G1. A temperature shift-down experiment suggested that MF involves a commitment point at late G1. In fast-growing cells, cADPR level peaked in G(1) and increased with increasing concentrations of glucose in the medium. Addition of glycolytic poison iodoacetate inhibited cell growth, reduced cADPR levels as well as the commitment of cell cycles in fast-growing cells. Commitment of MF cell cycles was induced by a cell permeant cADPR agonist, but blocked by a specific antagonist of cADPR-induced Ca(2+) release. Our results establish cADPR as a link between cellular metabolism and cell cycle control. |
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Authors:
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Connie M C Lam; Patrick K K Yeung; Hon Cheung Lee; Joseph T Y Wong |
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Publication Detail:
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Type: Journal Article Date: 2009-02-07 |
Journal Detail:
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Title: Cell calcium Volume: 45 ISSN: 1532-1991 ISO Abbreviation: Cell Calcium Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-25 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006226 Medline TA: Cell Calcium Country: Netherlands |
Other Details:
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Languages: eng Pagination: 346-57 Citation Subset: IM |
Affiliation:
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Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ADP-ribosyl Cyclase
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metabolism Animals Calcium / metabolism Cell Division* / drug effects Cell Membrane Permeability / drug effects Chelating Agents / pharmacology Cyclic ADP-Ribose / analogs & derivatives, antagonists & inhibitors, metabolism*, pharmacology Dinoflagellida / cytology*, drug effects, enzymology Glucose / pharmacology Inosine Nucleotides / pharmacology Iodoacetates / pharmacology Ionophores / pharmacology Models, Biological NAD / metabolism Temperature |
| Chemical | |
Reg. No./Substance:
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0/8-bromo-cyclic-ADP-ribose; 0/Chelating Agents; 0/Inosine Nucleotides; 0/Iodoacetates; 0/Ionophores; 0/cyclic IDP-ribose; 119340-53-3/Cyclic ADP-Ribose; 50-99-7/Glucose; 53-84-9/NAD; 7440-70-2/Calcium; EC 3.2.2.5/ADP-ribosyl Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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