| Cycles triggered with GnRH agonist: exploring low-dose HCG for luteal support. | |
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MedLine Citation:
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PMID: 20113955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study in patients at risk of ovarian hyperstimulation syndrome (OHSS) was to determine the efficacy and safety of luteal support using human chorionic gonadotrophin (HCG) after triggering ovulation with gonadotrophin-releasing hormone (GnRH) agonist in IVF/intracytoplasmic sperm injection antagonist cycles. A total of 192 OHSS-risk patients, following a GnRH antagonist protocol (0.25mg/day cetrorelix) during recombinant FSH stimulation, were triggered with 1.5mg s.c. leuproreline for ovulation. A total of three boluses of HCG were used for luteal support, 1000IU (group A, n=44), 500IU (group B, n=115) or 250IU (group C, n=33) every third day, starting the day after oocyte retrieval. For the reproductive outcome, main variables were biochemical and clinical pregnancy rates, and for OHSS, the variables were the numbers of moderate and severe OHSS cases. Overall pregnancy rate was 51.8% and clinical pregnancy rate was 43.4%. This study observed eight cases of moderate (4.2%) and seven of severe OHSS (3.6%). Six out of the seven (85.7%) severe cases were late-onset OHSS, related to pregnancy. In conclusion, GnRH agonist single dose for triggering ovulation and low doses of HCG used as luteal-phase support seem to secure a normal pregnancy outcome without increasing the OHSS risk. |
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Authors:
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J C Castillo; M Dolz; E Bienvenido; L Abad; E M Casañ; F Bonilla-Musoles |
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Publication Detail:
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Type: Journal Article Date: 2009-11-29 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 20 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 175-81 Citation Subset: IM |
Copyright Information:
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2009 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Hospital Clínico Universitario de Valencia, Blasco Ibañez Avenue 17, Valencia 46010, Spain. jccastillo@fiv-valencia.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / administration & dosage, therapeutic use* Female Fertility Agents, Female / administration & dosage, therapeutic use* Fertilization in Vitro Follicle Stimulating Hormone / therapeutic use Gonadotropin-Releasing Hormone / agonists* Humans Leuprolide / administration & dosage, therapeutic use* Oocyte Retrieval Ovarian Hyperstimulation Syndrome / prevention & control* Pregnancy Pregnancy Rate Retrospective Studies Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 33515-09-2/Gonadotropin-Releasing Hormone; 53714-56-0/Leuprolide; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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