Document Detail


Cycle of bovine lymphoblastoid cells parasitised by Theileria parva.
MedLine Citation:
PMID:  6818647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The events were studied which occurred during different stages of the cell cycle of bovine lymphoblastoid cells infected with the parasite Theileria parva. The mean number of nuclei in macroschizonts was about 16 for cells in interphase and 30 for those in metaphase. Pulse labelling with 3H thymidine showed that macroschizonts normally incorporated thymidine when the host cell was in early mitosis. Thymidine incorporation by macroschizonts thus occurred at a different stage in the cell cycle to that when the cell nucleus incorporated thymidine in S phase. DNA synthesis by host cell nucleus and macroschizont is thus asynchronous. Division of macroschizonts appears to follow immediately after they have synthesised DNA without a G2 period. This division occurs while the host cell is in metaphase. When the cell divides each daughter cell thus contains its interphase complement of macroschizont nuclei. Some macroschizont division may occur in interphase but this is relatively insignificant when compared with that which occurs in host cell metaphase. This work suggests that T parva regulates its own DNA synthesis independently of the cell. This finding could have application in developing strategies for chemotherapeutic attack on the parasite.
Authors:
A D Irvin; J G Ocama; P R Spooner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in veterinary science     Volume:  33     ISSN:  0034-5288     ISO Abbreviation:  Res. Vet. Sci.     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  298-304     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apicomplexa / growth & development*,  metabolism
Autoradiography
Cattle
Cell Cycle
Cell Line
Cell Nucleus / metabolism
DNA / biosynthesis
Lymphocytes / cytology*,  metabolism,  parasitology
Theileriasis
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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