| Cyclandelate in the treatment of cerebral arteriosclerosis. | |
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MedLine Citation:
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PMID: 811704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-one patients with cerebral arteriosclerosis were treated for twelve months with placebo or cyclandelate (Cyclospasmol), 400 mg four times daily, in a double-blind study with medication cross-over after six months. The group included 8 men and 13 women, with a mean age of 69 years. Each patient showed at least 5 of 9 signs or symptoms adopted as "inclusion criteria" for the study. Concomitant psychotropic or other drug therapy was standardized or matched during the trial, and periodic assessments were made of the patients' behavioral, physical, neurologic and psychiatric status. No serious side effects were observed. There was no significant difference between the cyclandelate and placebo phases in measurements of physical state. Changes on the gross behavior scales were insufficient for analysis. Tests of memory, control of manual dexterity and comprehension of everyday situations showed statistically significant improvement during the cyclandelate phase. In contrast to placebo, no measurable intellectual decline occurred during cyclandelate therapy. |
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Authors:
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P Hall |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 24 ISSN: 0002-8614 ISO Abbreviation: J Am Geriatr Soc Publication Date: 1976 Jan |
Date Detail:
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Created Date: 1976-02-20 Completed Date: 1976-02-20 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 41-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cyclandelate / administration & dosage, adverse effects, therapeutic use* Drug Evaluation Female Humans Intracranial Arteriosclerosis / drug therapy* Long-Term Care Male Mandelic Acids / therapeutic use* Mental Processes / drug effects Middle Aged Placebos |
| Chemical | |
Reg. No./Substance:
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0/Mandelic Acids; 0/Placebos; 456-59-7/Cyclandelate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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