Document Detail

Cyclandelate in the treatment of cerebral arteriosclerosis.
MedLine Citation:
PMID:  811704     Owner:  NLM     Status:  MEDLINE    
Twenty-one patients with cerebral arteriosclerosis were treated for twelve months with placebo or cyclandelate (Cyclospasmol), 400 mg four times daily, in a double-blind study with medication cross-over after six months. The group included 8 men and 13 women, with a mean age of 69 years. Each patient showed at least 5 of 9 signs or symptoms adopted as "inclusion criteria" for the study. Concomitant psychotropic or other drug therapy was standardized or matched during the trial, and periodic assessments were made of the patients' behavioral, physical, neurologic and psychiatric status. No serious side effects were observed. There was no significant difference between the cyclandelate and placebo phases in measurements of physical state. Changes on the gross behavior scales were insufficient for analysis. Tests of memory, control of manual dexterity and comprehension of everyday situations showed statistically significant improvement during the cyclandelate phase. In contrast to placebo, no measurable intellectual decline occurred during cyclandelate therapy.
P Hall
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  24     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-02-20     Completed Date:  1976-02-20     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
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MeSH Terms
Cyclandelate / administration & dosage,  adverse effects,  therapeutic use*
Drug Evaluation
Intracranial Arteriosclerosis / drug therapy*
Long-Term Care
Mandelic Acids / therapeutic use*
Mental Processes / drug effects
Middle Aged
Reg. No./Substance:
0/Mandelic Acids; 0/Placebos; 456-59-7/Cyclandelate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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