Document Detail


Cyborg cells: functionalisation of living cells with polymers and nanomaterials.
MedLine Citation:
PMID:  22509497     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Living cells interfaced with a range of polyelectrolyte coatings, magnetic and noble metal nanoparticles, hard mineral shells and other complex nanomaterials can perform functions often completely different from their original specialisation. Such "cyborg cells" are already finding a range of novel applications in areas like whole cell biosensors, bioelectronics, toxicity microscreening, tissue engineering, cell implant protection and bioanalytical chemistry. In this tutorial review, we describe the development of novel methods for functionalisation of cells with polymers and nanoparticles and comment on future advances in this technology in the light of other literature approaches. We review recent studies on the cell viability and function upon direct deposition of nanoparticles, coating with polyelectrolytes, polymer assisted assembly of nanomaterials and hard shells on the cell surface. The cell toxicity issues are considered for many practical applications in terms of possible adverse effects of the deposited polymers, polyelectrolytes and nanoparticles on the cell surface.
Authors:
Rawil F Fakhrullin; Alsu I Zamaleeva; Renata T Minullina; Svetlana A Konnova; Vesselin N Paunov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-16
Journal Detail:
Title:  Chemical Society reviews     Volume:  -     ISSN:  1460-4744     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0335405     Medline TA:  Chem Soc Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Biomaterials and Nanomaterials Group, Department of Microbiology, Faculty of Biology and Soil, Kazan (Idel buye\Volga region) Federal University, Kreml uramı 18, Kazan, 420008, Republic of Tatarstan, RF. kazanbio@gmail.com.
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