Document Detail

Cyathula prostrata: A potent source of anticancer agent against daltons ascites in Swiss albino mice.
MedLine Citation:
PMID:  23870465     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: To evaluate the anticancer activity of the methanolic extract of Cyathula prostrata in Ehrlich ascites carcinoma (EAC)-bearing mice with methotrexate as positive control in the advanced stage of tumorigenesis.
METHODS: EAC was induced in swiss albino mice by injecting 10(6) cell/mL of tumor cell suspension intraperitoneal. The methanolic extract of Cyathula prostrata effect on the tumor cell viability, DNA fragmentation and MTT assay were carried out.
RESULTS: Methanolic extract attenuated percentage increased in the cell survival time when compared to control group. However, the effect was less than that of methotrexat. Methotrexat and the extracts reversed the tumor-induced alterations in DNA fragmentation and MTT assay.
CONCLUSIONS: The present study suggests that the methanol extract of Cyathula prostrata has significant anticancer activity and that is comparable to that of methotrexate.
K Priya; S Krishnakumari; M Vijayakumar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of tropical medicine     Volume:  6     ISSN:  1995-7645     ISO Abbreviation:  Asian Pac J Trop Med     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-07-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101533720     Medline TA:  Asian Pac J Trop Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  776-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Hainan Medical College. Published by Elsevier B.V. All rights reserved.
PSG College of Arts and Science, Coimbatore, Tamilnadu, India-641014; Kongunadu Arts and Science College, Coimbatore, Tamilnadu, India-641029. Electronic address:
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