Document Detail


Cyanotoxins: bioaccumulation and effects on aquatic animals.
MedLine Citation:
PMID:  22363248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cyanobacteria are photosynthetic prokaryotes with wide geographic distribution that can produce secondary metabolites named cyanotoxins. These toxins can be classified into three main types according to their mechanism of action in vertebrates: hepatotoxins, dermatotoxins and neurotoxins. Many studies on the effects of cyanobacteria and their toxins over a wide range of aquatic organisms, including invertebrates and vertebrates, have reported acute effects (e.g., reduction in survivorship, feeding inhibition, paralysis), chronic effects (e.g., reduction in growth and fecundity), biochemical alterations (e.g., activity of phosphatases, GST, AChE, proteases), and behavioral alterations. Research has also focused on the potential for bioaccumulation and transferring of these toxins through the food chain. Although the herbivorous zooplankton is hypothesized as the main target of cyanotoxins, there is not unquestionable evidence of the deleterious effects of cyanobacteria and their toxins on these organisms. Also, the low toxin burden in secondary consumers points towards biodilution of microcystins in the food web as the predominant process. In this broad review we discuss important issues on bioaccumulation and the effects of cyanotoxins, with emphasis on microcystins, as well as drawbacks and future needs in this field of research.
Authors:
Aloysio da S Ferrão-Filho; Betina Kozlowsky-Suzuki
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-12-16
Journal Detail:
Title:  Marine drugs     Volume:  9     ISSN:  1660-3397     ISO Abbreviation:  Mar Drugs     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101213729     Medline TA:  Mar Drugs     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2729-72     Citation Subset:  IM    
Affiliation:
Laboratory of Evaluation and Promotion of Environmental Health, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, Manguinhos, Rio de Janeiro, RJ, Brazil. aloysio@ioc.fiocruz.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Toxins / metabolism*,  toxicity
Cyanobacteria / pathogenicity*
Microcystins / metabolism,  toxicity
Chemical
Reg. No./Substance:
0/Bacterial Toxins; 0/Microcystins
Comments/Corrections

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