Document Detail

Cyanoacrylate for colonic anastomosis; is it safe?
MedLine Citation:
PMID:  20066535     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This experimental study evaluated the effectiveness and safety of using cyanoacrylate adhesive for sutureless colonic anastomosis and as a protective seal to prevent leakage. METHODS: Sixty male Sprague-Dawley rats (300 +/- 10 g, 9 weeks old) were divided into three groups: in group I, the anastomosis was sutured in a single layer with 5-0 polypropylene; in group II, the anastomosis was fixed using N-butyl-2-cyanoacrylate (Histoacryl(R)); and in group III, the anastomosis was sutured and then sealed with N-butyl-2-cyanoacrylate. The rats were sacrificed on postoperative day 7. The anastomoses among the three groups were compared by measuring wound infection, anastomotic leakage, anastomotic stricture, adhesion formation, anastomotic bursting pressure, and histological appearance. RESULTS: No anastomotic leakage was observed in any group. Anastomotic stricture was significantly more extensive in groups II and III (p < 0.001). Bursting pressure was significantly lower in groups II and III (168 +/- 58, 45 +/- 21, and 60 +/- 38 mmHg for groups I to III, respectively, p < 0.001). The severity of inflammatory reactions was significantly greater and collagen deposition was significantly lower in groups II and III (p < 0.05). CONCLUSIONS: N-butyl-2-cyanoacrylate could be a useful method for sutureless colonic anastomosis based on the absence of anastomotic leakage, but it may impede healing of the colonic anastomosis. In addition, when used to seal sutured colonic anastomoses, cyanoacrylate may have a negative influence on anastomotic healing. The clinical use of N-butyl-2-cyanoacrylate in colonic anastomosis does not appear to be acceptable and safer anastomotic methods or alternative forms of cyanoacrylate should be developed.
Ki-Beom Bae; Sun-Hee Kim; Soo-Jin Jung; Kwan-Hee Hong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-12
Journal Detail:
Title:  International journal of colorectal disease     Volume:  25     ISSN:  1432-1262     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  601-6     Citation Subset:  IM    
Department of Surgery, Inje University College of Medicine, Busan Paik Hospital, 633-165 Gaegum-dong, Jin-gu, Busan, 614-735, Republic of Korea.
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MeSH Terms
Anastomosis, Surgical / adverse effects,  methods*
Colon / drug effects*,  surgery*
Constriction, Pathologic / pathology
Cyanoacrylates / adverse effects*,  pharmacology*
Intestinal Mucosa / drug effects,  pathology
Rats, Sprague-Dawley
Surgical Wound Dehiscence / pathology
Tissue Adhesions / pathology
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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