| Cyanide toxicity from sodium nitroprusside: risks and management. | |
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MedLine Citation:
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PMID: 1533553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review the risks, manifestations, and treatment of cyanide toxicity from nitroprusside therapy. DATA SOURCES: All English case reports identified in Index Medicus (MEDLINE) of cyanide intoxication related to nitroprusside from 1970 to the present were reviewed. In addition, literature regarding the incidence, risks, and treatment of cyanide toxicity from nitroprusside is presented. CONCLUSIONS: Numerous cases of cyanide toxicity associated with nitroprusside have been reported. The overall incidence appears to be infrequent; however, certain patients may be at high risk. Risk factors may include hypoalbuminemia, cardiopulmonary bypass procedures, or the administration of moderate to high doses of nitroprusside. Treatment of cyanide toxicity requires the cessation of nitroprusside and, for severe toxicity, use of the cyanide antidote kit. Cyanide toxicity from nitroprusside may be prevented by concomitant administration of sodium thiosulfate infusions. |
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Authors:
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J P Rindone; E P Sloane |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 26 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-06-05 Completed Date: 1992-06-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 515-9 Citation Subset: IM |
Affiliation:
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Department of Veterans Affairs Medical Center, Tucson, AZ 85723. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Cyanides / blood, poisoning* Humans Meta-Analysis as Topic Middle Aged Nitroprusside / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cyanides; 15078-28-1/Nitroprusside |
| Comments/Corrections | |
Erratum In:
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Ann Pharmacother. 1992 Sep;26(9):1160
[PMID:
1358281
]
Ann Pharmacother. 1992 Sep;26(9):1160 [PMID: 1358280 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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