Document Detail

Cyanide- and hydroxamate-resistant respiration in Neurospora crassa.
MedLine Citation:
PMID:  147864     Owner:  NLM     Status:  MEDLINE    
Strain inl-89601 of Neurospora crassa respires exclusively by means of the mitochondrial cytochrome chain. The respiration of this strain is entirely inhibited by cyanide or antimycin A, the classical inhibitors of cytochrome chain respiration. When this strain was grown in the presence of chloramphenicol, however, two additional terminal oxidases were detected. One of these oxidases is inhibited by substituted hydroxamic acids and has been described previously. The second oxidase was not inhibited by cyanide or hydroxamic acid but was inhibited by azide in the presence of both cyanide and hydroxamic acid. This azide-sensitive respiration was due to a single respiratory pathway with a Ki for azide of 200 micrometer. A small amount of azide-sensitive respiration was detected in mitochondrial fractions obtained from chloramphenicol-treated cells, and it is likely that the azide-sensitive oxidase is localized in the mitochondrion. The determinants for the azide-sensitive and hydroxamate-sensitive oxidases segregate in a Mendelian manner in crosses and are either unlinked or not closely linked to each other.
D L Edwards; B W Unger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bacteriology     Volume:  133     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-06-28     Completed Date:  1978-06-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1130-4     Citation Subset:  IM    
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MeSH Terms
Azides / pharmacology*
Chloramphenicol / pharmacology
Cyanides / pharmacology*
Hydroxamic Acids / pharmacology*
Mitochondria / metabolism
Neurospora / metabolism*
Neurospora crassa / drug effects,  growth & development,  metabolism*
Oxygen Consumption / drug effects*
Reg. No./Substance:
0/Azides; 0/Cyanides; 0/Hydroxamic Acids; 56-75-7/Chloramphenicol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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