| Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. | |
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MedLine Citation:
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PMID: 12759407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendritic cells play a major role in the induction of both innate and acquired immune responses against pathogenic invaders. These cells are also able to sense endogenous activation signals liberated by injured tissues even in the absence of infection. In the present work, we demonstrate that kinins mobilize dendritic cells to produce IL-12 through activation of the B(2) bradykinin receptor subtype and that bradykinin-induced IL-12 responses are tightly regulated both by angiotensin-converting enzyme, a kinin-degrading peptidase, and by endogenous IL-10. Using a mouse model of allergic inflammation, we further show that addition of bradykinin to OVA during immunization results in decreased eosinophil infiltration on Ag challenge. The latter effect was demonstrated to be due to IL-12-driven skewing of Ag-specific T cell responses to a type 1 cytokine profile. Our data thus indicate that kinin peptides can serve as danger signals that trigger dendritic cells to produce IL-12 through activation of B(2) bradykinin receptors. |
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Authors:
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Julio Aliberti; João P B Viola; Adriana Vieira-de-Abreu; Patricia T Bozza; Alan Sher; Julio Scharfstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 170 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-21 Completed Date: 2003-09-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 5349-53 Citation Subset: AIM; IM |
Affiliation:
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Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA. jalberti@niaid.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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administration & dosage,
pharmacology,
physiology Animals Bradykinin / administration & dosage, physiology* Cell Movement / drug effects, immunology Dendritic Cells / drug effects, immunology*, metabolism* Disease Models, Animal Eosinophils / drug effects, pathology Female Immunity, Innate / drug effects, genetics Injections, Intraperitoneal Interleukin-12 / biosynthesis*, physiology Kallidin / administration & dosage, pharmacology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Ovalbumin / administration & dosage, immunology Pleurisy / immunology, pathology Receptor, Bradykinin B2 Receptors, Bradykinin / deficiency, genetics Spleen / cytology, drug effects, immunology, metabolism Th1 Cells / drug effects, immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Receptor, Bradykinin B2; 0/Receptors, Bradykinin; 187348-17-0/Interleukin-12; 342-10-9/Kallidin; 58-82-2/Bradykinin; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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